Resources

Poster Presentations

Melanocortin Receptor-1 Program Posters

The following poster presentations made at scientific and medical conferences report on results of the preclinical and clinical studies with PL-8177 for inflammatory bowel disease.

Probing the Role of the MC1 Receptor Agonists in Diverse Immunological Diseases

May 2018

Carl Spana, Andrew W. Taylor, David G. Yee, Marie Mahklina, Wei Yang, John Dodd, Presented at TIDES: Oligonucleotide and Peptide Therapeutics 2018

Probing the Role of the MC1 Receptor in Resolution with a Selective MC1 Receptor Agonist – PL-8177

March 2018

Carl Spana, Marle Mahklina, Wei Yang, John Dodd, Presented at: 2018 Keystone Symposia Conference, Royal Dublin Society, Dublin, Ireland

Natriuretic Peptide Program Posters

The following poster presentations made at scientific and medical conferences report on results of the preclinical and clinical studies with PL-3994 for heart failure.

Conditional cardiomyocyte-restricted CorinKO mice demonstrate increasedcardiac hypertrophy and pro-fibroticgene activation in response to TACand PL-3994-a novel selective GC-A receptor peptide agonist rescues the phenotype

2015

Xu B, Dodd J, Spana C, Houser S, Dries D, Conditional cardiomyocyte-restricted corin KO mice demonstrate enhanced cardiac hypertrophy and fibrosis in response to TAC and PL-3994 - a novel selective GC-A receptor peptide agonist rescues the phenotype...

Phase IIa Study of the NPR-Agonist, PL-3994, in Healthy Adult Volunteers with Controlled Hypertension

September 2009

Sica D, Jordan R, Fischkoff S, Phase IIa Study of the NPR-Agonist, PL-3994, in Healthy Adult Volunteers with Controlled Hypertension...

Phase 1 Study of the Novel A-Type Natriuretic Receptor Agonist, PL-3994, in Healthy Volunteers

September 2008

Jordan R, Stark J, Huskey S, Lata J, Hallam T, Fischkoff S. Phase 1 Study of the Novel A-Type Natriuretic Receptor Agonist, PL-3994, in Healthy Volunteers, Poster Presentation at the 12th Annual Scientific Meeting of the HFSA, September 21-24, 2008, Toronto, Ontario, Canada, Poster 220...