Resources

PL-3994 Heart Failure Posters

Poster Presentations on PL-3994 for Heart Failure

The following poster presentations made at scientific and medical conferences report on results of the preclinical and clinical studies with PL-3994 for heart failure.

Conditional cardiomyocyte-restricted CorinKO mice demonstrate increasedcardiac hypertrophy and pro-fibroticgene activation in response to TACand PL-3994-a novel selective GC-A receptor peptide agonist rescues the phenotype

2015

Xu B, Dodd J, Spana C, Houser S, Dries D, Conditional cardiomyocyte-restricted corin KO mice demonstrate enhanced cardiac hypertrophy and fibrosis in response to TAC and PL-3994 - a novel selective GC-A receptor peptide agonist rescues the phenotype...

Phase IIa Study of the NPR-Agonist, PL-3994, in Healthy Adult Volunteers with Controlled Hypertension

September 2009

Sica D, Jordan R, Fischkoff S, Phase IIa Study of the NPR-Agonist, PL-3994, in Healthy Adult Volunteers with Controlled Hypertension...

Phase 1 Study of the Novel A-Type Natriuretic Receptor Agonist, PL-3994, in Healthy Volunteers

September 2008

Jordan R, Stark J, Huskey S, Lata J, Hallam T, Fischkoff S. Phase 1 Study of the Novel A-Type Natriuretic Receptor Agonist, PL-3994, in Healthy Volunteers, Poster Presentation at the 12th Annual Scientific Meeting of the HFSA, September 21-24, 2008, Toronto, Ontario, Canada, Poster 220...