Publications

Bremelanotide
Publications

Diamond, L.E., Earle, D.C., Garcia, W.D., and Spana C. Co-administration of low doses of intranasal PT-141, a melanocortin receptor antagonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology 2005; 65:755-759.

Pfaus, J.G., Shadiack, A.M., van Soest T., Tse, M., and Molinoff, P.B. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proc Natl Acad Sci USA 2004; 101: 10201-10204.

Rosen R.C., Diamond, L.E., Earle D.C., Shadiack, A.M.,and Molinoff, P.B. Evaluation of the safety, pharmacokinetics, and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra®. Int J Impot Res 2004; 16: 135-142.

Diamond, L.E., Earle, D.C., Rosen, R.C., Willet, M.S. and Molinoff, P.B. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res 2004; 16: 51-59.

Molinoff, P.B., Shadiack, A.M., Earle D., Diamond, L.E. and Quon, C.Y. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann NY Acad Sci 2003; 994: 96-102.

Wessells, H., Gralnek D., Dorr R., Hruby V., Hadley M. and Levine N. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56: 641-646.

Wessells, H., Levine N., Hadley M.E. , Dorr R. and Hruby V. Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Melanotan II. Int J Impot Res 2000; 12: 574-579.

Wessells, H., Fuciarelli K., Hansen J., Hadley M., Hruby V., Dorr R. and Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind crossover placebo-controlled study. J Urology 1998; 160: 389-393.

Bremelanotide
Abstracts

Wessels, H., Padma-Nathan, H., Raifer, J., Feldman, R., Rosen, R., Molinoff, P., Diamond, L., Earle, D., and Powers B. At-home efficacy of an intranasally administered melanocortin receptor agonist, PT-141, in men with erectile dysfunction (ED). (May 2004) American Urology Association.

Pfaus, J.G., van Soest T., Shadiack, A.M. and Molinoff, P.B. Effects of PT-141, a selective melanocortin receptor agonist, on sexual behavior in female rats. (November 2002) Society for NeuroScience Program #482.4.

Shadiack, A.M. van Soest, T., Pfaus, J.G. and Molinoff, P.B. Selective facilitation of sexual solicitation in the female rat by the melanocortin analogue PT-141. (October 2002) International Society for the Study of Women's Sexual Health.

Diamond, L.E., Earle , D.C. , Shadiack, A.M., Rosen, R.C. and Molinoff, P.B. An evaluation of the safety and efficacy of intranasally administered PT-141. (September 2002) 10th World Congress of the International Society for Sexual and Impotence Research. S20.

Molinoff, P.B., Earle D., Shadiack, A.M., Pfaus, J.G. and Rosen, R. Intranasal delivery of PT-141, a melanocortin agonist for the treatment of sexual dysfunction. (August 2002) 5th International Melanocortin Meeting Abstracts, p 35.

Pfaus, J.G., van Soest, T. and Shadiack, A.M. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. (June 2002) Soc. Behav. Neuroendo.

Molinoff, P., Earle, D., Shadiack, A.M. and Rosen, R. A double blind, placebo-controlled, dose-escalation study to maximum tolerated dose to evaluate the safety, pharmacokinetics, and pharmacodynamic effect of subcutaneously administered PT-141 in healthy male subjects. (May 2002) American Urology Association.

Shadiack, A.M., DiPietro, N., van Soest, T. and Pfaus, J.G. alpha-MSH analog facilitates appetitive sexual behavior in female rats. (October 2001) Female Sexual Function Forum. 125.

Herbert, G.W., Koegler F.G., Cameron J.L. and Shadiack, A.M. Effects of PT-141 on erectile function and other behaviors in adult male sprague-dawley rats and rhesus macaques. (June 2001) American Urological Association meeting transcript.